首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Metabolic and endocrine effects of water and/or food deprivation in rats
Authors:Kasdallah Abir Grissa  Mornagui Bessem  Gharbi Najoua  Machghoul Salem  El-Fazâa Saloua
Institution:Laboratoire de Physiologie Animale, Département de Biologie, Faculté des Sciences de Tunis-El-Manar, Campus Universitaire, 1060 Tunis, Tunisie. abirgrissa@yahoo.fr
Abstract:Metabolic and endocrine effects of water and/or food deprivation in rats. We aim at studying the effect of water deprivation, food deprivation and their combination for three days on adrenal cortex, pituitary-thyroid axis and vasopressinergic system activity in rats. Corticosterone level was determined by fluorimetric method. The levels of free thyroxine (FT4) and thyroid stimulating hormone (TSH) were determined by immunoenzymatic assay and vasopressin (AVP) level was determined by radio-immunoassay. In all three groups, basal levels of plasma corticosterone were increased. A thyroid dysfunction was shown after water deprivation, food deprivation and their combination reflected by a significant decrease in FT4 levels. Paradoxically, a significant decrease in TSH level was observed in food-deprived rats and in rats subjected to simultaneous food and water deprivation, while a slight and not significant decrease in TSH level was shown in water-deprived rats. A significant increase in plasma AVP level was observed after water deprivation and simultaneous water and food deprivation, while no change was found after food deprivation. The data indicated that water deprivation, food deprivation and their combination stimulated the adrenal cortex, thereby suggesting a stress state. On the other hand, it seems that nutritional stress modifies the pituitary-thyroid axis through mechanisms different from those of osmotic stress. Moreover, it seems that food deprivation partially prevented the stimulatory effect of water deprivation on vasopressinergic system.
Keywords:Corticostérone  Privation hydrique  Privation alimentaire  Thyroxine libre (FT4)  Thyréostimuline (TSH)  Vasopressine (AVP)  Corticosterone  Water deprivation  Food deprivation  Free thyroxine (FT4)  Thyroid-stimulating hormone (TSH)  Vasopressin (AVP)
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号