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Antimicrobial Activity of Bacillus amyloliquefaciens ANT1 Toward Pathogenic Bacteria and Mold: Effects on Biofilm Formation |
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| Authors: | Rosa Anna Nastro Anthony Arguelles-Arias Marc Ongena Amelia Di Costanzo Marco Trifuoggi Marco Guida Patrick Fickers |
| Affiliation: | 1. Department of Sciences for the Environment, University Parthenope of Naples, Centro Direzionale Isola C4, 80143, Naples, Italy 3. Centre d’Ingenierie des Proteines, Bacterial Physiology and Genetics, Allée de la chimie, Université de Liège, Bat. B6, 4000, Liège, Belgium 4. Unité de Bio-Industrie, Gembloux Agro-Bio Tech, Université de Liège, Passage des Déportés, 5030, Gembloux, Belgium 5. Department of Biology, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Via Cinthia 5, 80126, Naples, Italy 6. Department of Chemical Sciences, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Ed.4, Via Cinthia 5, 80126, Naples, Italy 7. Department of Biology, University Federico II of Naples, Complesso Universitario di Monte Sant’Angelo, Ed.7, Via Cinthia 5, 80126, Naples, Italy 2. Unité de Biotechnologies et Bioprocédés, Université Libre de Bruxelles, Av F.-D. Roosevelt, 50, CP165/61, 1050, Brussels, Belgium |
| Abstract: | The intensive use and misuse of antibiotics over the last decades have generated a strong selective pressure for the emergence of multi-resistant strains and nosocomial infections. Biofilm has been demonstrated as a key parameter in spreading infections, especially in hospitals and healthcare units. Therefore, the development of novel anti-biofilm drugs is actually of the upmost importance. Here, the antimicrobial and antibiofilm activities toward pathogenic microorganisms of a set of non-ribosomal synthesized peptides and polyketides isolated from Bacillus amyloliquefaciens ANT1 culture supernatant are presented. |
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