Lactobacillus paracasei DSMZ16671 Reduces Mutans Streptococci: A Short-Term Pilot Study |
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Authors: | Caterina Holz Christiane Alexander Christina Balcke Margret Moré Annegret Auinger Maren Bauer Lauren Junker Jörg Grünwald Christine Lang Markus Pompejus |
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Affiliation: | 1. ORGANOBALANCE GmbH, Gustav-Meyer-Allee 25, 13355, Berlin, Germany 2. analyze&realize AG, Waldseeweg 6, 13467, Berlin, Germany 3. BASF New Business GmbH, 4 Gartenweg-Z25, 67063, Ludwigshafen, Germany 5. BASF SE, Carl-Bosch-Strasse 38, 67063, Ludwigshafen, Germany 4. BASF Corporation, Fine Chemical and Biocatalysis Research, 500 White Plains Road, Tarrytown, NY, 10591, USA 6. BASF Corporation, Research Bioactive Materials, 500 White Plains Road, Tarrytown, NY, 10591, USA
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Abstract: | Reducing the burden of pathogenic mutans streptococci is a goal of oral health. Lactobacillus paracasei DSMZ16671, even after heat-killing, specifically co-aggregates mutans streptococci in vitro and retains this activity in human saliva. In rats, it reduces mutans streptococcal colonization of teeth and caries scores. This pilot study sought to assess the potential of heat-killed L. paracasei DSMZ16671 (pro-t-action®) to reduce levels of salivary mutans streptococci in humans, using sugar-free candies as a delivery vehicle. A randomized, placebo-controlled, double-blind in vivo study of three groups examined the short-term effect of sugar-free candies containing 0 (placebo), 1, or 2 mg/candy piece of heat-killed L. paracasei DSMZ16671 on the levels of salivary mutans streptococci determined before and after consumption of the candies. The candies were consumed 4 times during 1.5 consecutive days. Compared to the placebo group, the test groups’ saliva had significantly reduced mutans streptococci as an immediate effect. These results suggest the use of heat-killed L. paracasei DSMZ16671 in suckable candies as a method to reduce mutans streptococci in the mouth and, thereby, caries risk. We think this a new concept and strategy for caries prevention and management. |
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