Comparative studies of quinacrine-positive neurones in the myenteric plexus of stomach and intestine of guinea-pig,rabbit and rat |
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| Authors: | Rahima Crowe Professor Geoffrey Burnstock |
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| Institution: | (1) Department of Anatomy and Embryology and Centre for Neuroscience, University College London, London, England;(2) Department of Anatomy and Embryology, University College London, Gower St., WC1E 6BT London, England |
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| Abstract: | Summary The number of quinacrine-fluorescent nerve cell bodies and the percentage of the ganglion area occupied by this fluorescence within stretch preparations of the myenteric plexus of the stomach and ileum of the guineapig, rabbit and rat were assessed. The number of quinacrine-positive cell bodies per cm2 of plexus varied between 1045 in the rabbit ileum to 2633 in the rat stomach, whilst the percentage of the ganglionic area occupied by fluorescence was approximately 10 %. The distribution of quinacrine-fluorescent nerve fibres and cell bodies in the myenteric plexus was compared to the distribution of nerves revealed by catecholamine fluorescence and by staining for acetylcholinesterase in the stomach and ileum of all three species. Quinacrine fluorescence appears to be selective for non-adrenergic, non-cholinergic nerves; the possibility that it binds to high levels of ATP is discussed. |
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| Keywords: | Quinacrine Myenteric plexus Non-adrenergic non-cholinergic nerves Guinea-pig Rabbit Rat ATP |
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