Platelet activation of mechanical versus bioprosthetic heart valves during systole |
| |
| Affiliation: | 1. Department of Biomedical Engineering, National University of Singapore, Singapore;2. Department of Biomedical Engineering, Tulane University, United States of America;3. Department of Cardiology, National University Heart Centre, Singapore;4. School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore;1. Department of Cardiac Surgery, Medical University of Bialystok, Poland;2. Department of Cardiology, Medical University of Bialystok, Poland;3. Department of Population Medicine and Prevention of Civilization Diseases, Medical University of Bialystok, Poland;4. Department of Invasive Cardiology, Medical University of Bialystok, Poland;5. Department of Hematology, Medical University of Bialystok, Poland;1. Department of Mathematics, University of North Carolina, Chapel Hill, NC, USA;2. Medical Computing Group, Kitware, Inc., Carrboro, NC, USA;3. Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, USA;4. Division of Cardiology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA;5. Department of Mathematics and McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA |
| |
| Abstract: | Thrombus formation is a major concern for recipients of mechanical heart valves (MHVs), which requires them to take anticoagulant drugs for the rest of their lives. Bioprosthetic heart valves (BHVs) do not require life-long anticoagulant therapy but deteriorate after 10–15 years. The thrombus formation is initiated by the platelet activation which is thought to be mainly generated in MHVs by the flow through the hinge and the leakage flow during the diastole. However, our results show that the activation in the bulk flow during the systole phase might play an essential role as well. This is based on our results obtained by comparing the thrombogenic performance of a MHV and a BHV (as control) in terms of shear induced platelet activation under exactly the same conditions. Three different mathematical activation models including linear level of activation, damage accumulation, and Soares model are tested to quantify the platelet activation during systole using the previous simulations of the flow through MHV and BHV in a straight aorta under the same physiologic flow conditions. Results indicate that the platelet activation in the MHV at the beginning of the systole phase is slightly less than the BHV. However, at the end of the systole phase the platelet activation by the bulk flow for the MHV is several folds (1.41, 5.12, and 2.81 for linear level of activation, damage accumulation, and Soares model, respectively) higher than the BHV for all tested platelet activation models. |
| |
| Keywords: | Platelet activation Mechanical heart valve Bioprosthetic heart valve Eulerian framework Systole phase |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
