Calculated ventilation and effort distribution as a measure of respiratory disease and Heliox effectiveness |
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| Affiliation: | 1. INRIA Paris, 2 Rue Simone Iff, 75012 Paris, France;2. Sorbonne Universités, UPMC Univ. Paris 6, Laboratoire Jacques-Louis Lions, 75252 Paris, France;3. Medical R&D, WBL Healthcare, Air Liquide Santé International, 1 Chemin de la Porte des Loges, 78350 Les Loges-en-Josas, France;4. Department of Mechanical Engineering, Lafayette College, Easton, PA 18042, USA;1. Biomedical Engineering, University of Strathclyde, UK;2. Institute for Applied Health Research, Glasgow Caledonian University, UK;3. School of Health Sciences, University of Salford, UK;4. Stroke MCN, NHS Lanarkshire, UK;1. Department of Sports Medicine and Health Promotion, Friedrich-Schiller University Jena, Wöllnitzer Straße 42, D-07749 Jena, Germany;2. Center of Interdisciplinary Prevention of Diseases related to Professional Activities, Friedrich-Schiller University Jena, D-07737 Jena, Germany;3. Department of Sports and Motion Science, University Stuttgart, Allmandring 28, D-70569 Stuttgart, Germany;4. Department of Sports Management, University Bayreuth, Universitätsstraße 30, D-95440 Bayreuth, Germany;1. Department of Engineering, Faculty of Science and Technology, Aarhus University, Finlandsgade 22, 8200 Aarhus N, Denmark;2. Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;3. Department of Clinical Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark;1. Department of Oral Cell Biology and Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands;2. MOVE Research Institute Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands;3. Biomechanics Section, Department of Mechanical Engineering, KU Leuven, Leuven, Belgium;4. Department of Oral Kinesiology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands |
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| Abstract: | In spite of numerous clinical studies, there is no consensus on the benefit Heliox mixtures can bring to asthmatic patients in terms of work of breathing and ventilation distribution. In this article we use a 3D finite element mathematical model of the lung to study the impact of asthma on effort and ventilation distribution along with the effect of Heliox compared to air. Lung surface displacement fields extracted from computed tomography medical images are used to prescribe realistic boundary conditions to the model. Asthma is simulated by imposing bronchoconstrictions to some airways of the tracheo-bronchial tree based on statistical laws deduced from the literature. This study illuminates potential mechanisms for patient responsiveness to Heliox when affected by obstructive pulmonary diseases. Responsiveness appears to be function of the pathology severity, as well as its distal position in the tracheo-bronchial tree and geometrical position within the lung. |
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| Keywords: | Asthma Lung Mathematical modeling Stochastic respiratory tree |
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