Consistent trilayer biomechanical modeling of aortic valve leaflet tissue |
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| Institution: | 1. Departments of Civil & Environmental Engineering and Electrical Engineering & Computer Science, University of California, Berkeley, United States;2. Department of Civil & Environmental Engineering, University of California, Berkeley, United States;3. Molecular Cell Biomechanics Laboratory, Departments of Bioengineering and Mechanical Engineering, University of California, Berkeley, United States;1. University of Toronto Institute of Biomaterials and Biomedical Engineering, Toronto, Ontario, Canada;2. Sunnybrook Research Institute, Holland Musculoskeletal Research Program, Toronto, Ontario, Canada;1. Anshin Hospital, 1-4-12, Minatojima Minamimachi, Chuo-ku, Kobe City, Hyogo, Japan;2. Department of Physical Therapy, Faculty of Rehabilitation, Kobe Gakuin University, 518 Ikawadanicho, Arise, Nishi-ku, Kobe, Hyogo 651-2180, Japan;3. Department of Physical Therapy, School of Health Sciences, Tokyo University of Technology, 5-23-22, Nishikamata, Ota-ku, Tokyo, Japan;1. Biomechanics Research Laboratory, Department of Industrial Engineering, University of Miami, Coral Gables, FL, United States;2. Orthopaedic Biomechanics Laboratory, Department of Biomedical Engineering, University of Miami, Coral Gables, FL, United States;1. Dept. of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom;2. Dept. of Experimental Psychology, University of Oxford, Oxford, United Kingdom;3. Translational Imaging Group, Centre for Medical Image Computing, UCL, London, United Kingdom;4. Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom;1. Program for Neurotrauma, Neuroproteomics & Biomarkers, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA;2. The Departments of Psychiatry, University of Florida, Gainesville, FL 32611, USA;3. Schizophrenia Research Foundation, R/7A, North Main Road, Anna Nagar West Extension, Chennai, Tamil Nadu 600101, India |
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| Abstract: | Aortic valve tissue exhibits highly nonlinear, anisotropic, and heterogeneous material behavior due to its complex microstructure. A thorough understanding of these characteristics permits us to develop numerical models that can shed insight on the function of the aortic valve in health and disease. Herein, we take a closer look at consistently capturing the observed physical response of aortic valve tissue in a continuum mechanics framework. Such a treatment is the first step in developing comprehensive multiscale and multiphysics models.We highlight two important aspects of aortic valve tissue behavior: the role of the collagen fiber microstructure and the native prestressing. We propose a model that captures these two features as well as the heterogeneous layer-scale topology of the tissue. We find the model can reproduce the experimentally observed multiscale mechanical behavior in a manner that provides intuition on the underlying mechanics. |
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| Keywords: | Aortic valve Fiber micromechanics Anisotropy Multiscale Multiphysics |
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