Auspicious role of the steroidal heterocyclic derivatives as a platform for anti-cancer drugs |
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| Affiliation: | 1. Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt;2. TWINCORE, Centre for Experimental and Clinical Infection Research, Feodor-Lynen-Str. 7, 30625 Hannover, Germany;3. Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt;1. Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary;2. 1st Department of Medicine, University of Szeged, Korányi fasor 8–10, H-6720 Szeged, Hungary;3. Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary;1. Department of Chemistry, Islamia College of Science and Commerce, Srinagar 190009, India;2. Department of Chemistry and Biochemistry, University of Arizona, Tucson 85721, USA;3. Department of Chemistry, University of Kashmir, Hazratbal, Srinagar 190002, India;1. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Mexico, D.F. 04510, Mexico;2. Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Avenida Vasco de Quiroga No. 15, Col. Belisario Domínguez, Sección XVI, México, D.F. 14080, Mexico;3. Instituto de Química, Universidad Nacional Autónoma de México, México, D.F. 04510, Mexico;1. Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt;2. Department of Chemistry, Faculty of Science, Helwan University, Cairo, Egypt;3. Department of Chemistry, Faculty of Science, Tabuk University, P.O. Box 741, Tabuk 71491, Kingdom of Saudi Arabia;4. Basic Science Department, Modern Academy For Engineering and Technology in Maadi, Egypt |
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| Abstract: | Steroids are polycyclic compounds that have a wide range of biological activities. They are bio-synthesized from cholesterol through a series of enzyme-mediated transformations, so they are highly lipophilic and readily enter most cells to interact with intracellular receptors, making them ideal vehicles for targeting a broad array of pathologies. New curative agents for cancers have been developed from several steroidal derivatives. Some biologically important properties of modified steroids are dependent on structural features of the steroid moiety and their side chains. Therefore, chemical derivatization of steroids provides a way to modify their function, and many structure–activity relationships have been confirmed by such synthetic modifications. Several studies demonstrate that steroidal heterocyclic derivatives can be effective in the prevention and treatment of many types of hormone-dependent cancers. The present review is a concise report on steroidal heterocyclic derivatives, with special emphasis on steroid heterocyclic derivatives with 5 membered rings or six-membered rings having interesting therapeutic potential as enzyme inhibitors and cytotoxic drugs to be used as candidates for anti-cancer drug development. |
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| Keywords: | Anti-cancer Steroids Heterocyclic compounds Five-membered rings Six-membered rings |
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