Synthesis,characterization and DNA binding studies of platinum(II) complexes with benzimidazole derivative ligands |
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Institution: | 1. Unidad Asociada Neurodeath CSIC-UCLM, Departamento de Ciencias Médicas, Facultad de Farmacia, Universidad de Castilla-La Mancha, Campus Universitario de Albacete, 02071 Albacete, Spain;2. Departamento de Química Inorgánica, Orgánica y Bioquímica, Universidad de Castilla-La Mancha, Facultad de Farmacia, Campus Universitario de Albacete, 02071 Albacete, Spain;3. Departamento de Química-Física, Universidad de Castilla-La Mancha, Facultad de Farmacia, Campus Universitario de Albacete, 02071 Albacete, Spain;4. Departamento de Química Inorgánica, Orgánica y Bioquímica, Universidad de Castilla-La Mancha, Facultad de Ciencias y Tecnologías Químicas, Campus Universitario de Ciudad Real, 13071 Ciudad Real, Spain;5. Departamento de Química-Física, Universidad de Castilla-La Mancha, Facultad de Ciencias y Tecnologías Químicas, Campus Universitario de Ciudad Real, 13071 Ciudad Real, Spain;6. Unidad Asociada Neurodeath CSIC-UCLM, Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Castilla-La Mancha, Campus Universitario de Albacete, 02071 Albacete, Spain;7. CIBERNED, Instituto de Salud Carlos III, Madrid, Spain |
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Abstract: | The aim of this study was to synthesize and evaluate plasmid DNA interaction of new platinum(II) complexes with some 2-substituted benzimidazole derivatives as carrier ligands which may have potent anticancer activity and low toxicity. Twelve benzimidazole derivatives carrying indole, 2-/or 3-/or 4-methoxyphenyl, 4-methylphenyl, 3,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl, 4-methoxybenzyl, 3,4,5-trimethoxybenzyl, 3,4,5-trimethoxystyryl, 3,4,5-trimethoxybenzylthio or dimethylamino ethyl groups in their position 2 and twelve platinum(II) complexes with these carrier ligands were synthesized. The chemical structure of the platinum complexes have been characterized by their elemental analysis and FIR, 1H NMR and mass spectra and their 1H NMR and FIR spectra were interpreted by comparison with those of the ligands. The interaction of all the ligands and their complexes with plasmid DNA and their restriction endonuclease reactions by BamHI and HindIII enzymes were studied by agarose gel electrophoresis. It was determined that complex 1 dichloro-di(2-(1H-indole-3-yl)benzimidazole)platinum(II)·2H2O] has stronger interaction than carboplatin and complex 10 dichloro-di(2-(3,4,5-trimethoxystyryl)benzimidazole)platinum(II)·2H2O] has stronger interaction than both carboplatin and cisplatin with plasmid DNA. |
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Keywords: | Benzimidazole Platinum(II) complex pBR322 plasmid DNA |
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