Linkage of the structural gene for uroporphyrinogen I synthase to markers on mouse chromosome 9 in a cross between feral and inbred mice |
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| Authors: | Tammy K Antonucci Verne C Chapman Miriam H Meisler |
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| Institution: | (1) Department of Human Genetics, University of Michigan Medical School, 48109 Ann Arbor, Michigan;(2) Department of Molecular Biology, Roswell Park Memorial Institute, 14263 Buffalo, New York |
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| Abstract: | The Ups locus has been mapped to mouse chromosome 9 in a three-point cross. The observed gene order is centromere-Ups-15-Mpi-1-22-Mod-1. Ups is unlinked to Lv, which encodes the previous enzyme in the heme biosynthesis pathway. Feral mice collected at Skive, Denmark, have been characterized at several biochemical loci; multiple differences from inbred strains make this a useful stock for linkage analysis.Supported by USPHS Grants GM 24872 and GM 19521. |
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| Keywords: | heme porphobilinogen deaminase Skive isozymes |
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