IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment |
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Authors: | Liu Haofei Cai Mingchao Yang Chun Zheng Jie Bach Richard Kural Mehmet H Billiar Kristen L Muccigrosso David Lu Dongsi Tang Dalin |
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Institution: | Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA. |
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Abstract: | Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated. |
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