Genome stability versus transcript diversity |
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| Affiliation: | 1. Environmental Engineering Laboratory, Departament d''Enginyeria Quimica, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Spain;2. Environmental Chemistry Department, IDAEA-CSIC, Jordi Girona, 18-26, 08034 Barcelona, Spain;1. Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, South Korea;2. BK21Plus Team for Anti-aging Biotechnology and Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, South Korea;3. Department of Tropical Medicine, and Inha Research Institute for Medical Sciences, Inha University School of Medicine, Incheon 22212, South Korea;4. Department of Microbiology, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon 21986, South Korea;1. Glickman Urological & Kidney Institute—Cleveland Clinic Foundation, Cleveland, OH;2. Case Western Reserve University School of Medicine—Cleveland, OH |
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| Abstract: | Our genome is protected from the introduction of mutations by high fidelity replication and an extensive network of DNA damage response and repair mechanisms. However, the expression of our genome, via RNA and protein synthesis, allows for more diversity in translating genetic information. In addition, the splicing process has become less stringent over evolutionary time allowing for a substantial increase in the diversity of transcripts generated. The result is a diverse transcriptome and proteome that harbor selective advantages over a more tightly regulated system. Here, we describe mechanisms in place that both safeguard the genome and promote translational diversity, with emphasis on post-transcriptional RNA processing. |
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| Keywords: | RNA splicing RNA transcription Protein translation Post-transcriptional RNA processing DNA damage response DNA repair Polymerase fidelity Proteomic diversity |
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