Effect of O2-monobutyryl guanosine 3', 5'-cyclic monophosphate on hepatic metabolism of free fatty acids. |
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Authors: | C Soler-Argilaga R L Russell M Heimberg |
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Institution: | Department of Pharmacology, School of Medicine University of Missouri, Columbia, Missouri 65201 USA |
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Abstract: | Livers from fed male rats were perfused with O2′-monobutyryl guanosine 3′,5′-cyclic monophosphate. The output of triglyceride was reduced, while output of ketone bodies and glucose was stimulated by 10?4M monobutyryl guanosine 3′,5′-cyclic monophosphate. No effect was observed with 10?5 M nucleotide. Monobutyryl guanosine 3′,5′-cyclic monophosphate did not affect uptake of free fatty acids. In these respects, monobutyryl guanosine 3′,5′-cyclic monophosphate mimics the effects of dibutyryl adenosine 3′,5′-cyclic monophosphate, although the guanylic nucleotide seems to be less potent than the adenosine 3′,5′-cyclic monophosphate derivative. |
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