伊班膦酸钠联合化疗治疗恶性肿瘤骨转移的临床观察

目的:探讨伊班膦酸钠联合化疗治疗恶性骨转移的临床疗效.方法:采用随机分组的方法将60例病人分为二组:单纯化疗组:根据原发肿瘤采用相应的治疗方案;联合治疗组:在化疗基础上联合邦罗力治疗.结果:骨转移灶疗效评价:联合治疗组的有效率为50%,单纯化疗组的有效率为23.3%,前者的疗效明显优于后者,且有显著性差异(p＜0.05);止痛疗效评价:联合治疗组的有效率为83.3%,单纯化疗组的有效率为53.3%,前者明显优于后者,且有显著性差异(p＜0.05).结论:伊班膦酸钠的不良反应轻,联合化疗可显著增强疗效,改善患者体能状态.

A Clinical Observation of Ibandronate Combined with Chemotherapy in Treatment of Malignant Bone Metastases

Objective:To study the clinical effect of ibandronate combined with chemotherapy on the treatment of malignant bone metastases.Methods:60 patients were randomized into two groups:30 patients in chemotherapy group receiving normal chemotherapy, 30 patients in combination group treated with both chemotherapy and ibandronate.The effects were evaluated when two cycles were fin- ished.Results:The overall response rate of bone metastases in chemotherapy group and combination group was 23.3% and 50% respec- tively.The overall response rate of pain relief in chemotherapy group and combination group was 53.3% and 83.3% respectively.Conclu- sion:Ibandronate combined chemotherapy significantly increased therapeutic effect,and improved physical state of patients,accompa- nied with mild side-effect.