Fiber-based tissue engineering: Progress,challenges, and opportunities |
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| Authors: | Ali Tamayol Mohsen Akbari Nasim Annabi Arghya Paul Ali Khademhosseini David Juncker |
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| Affiliation: | 1. Biomedical Engineering Department and McGill University, Genome Quebec Innovation Centre, Montreal, Canada H3A 0G1;2. Center for Biomedical Engineering, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Cambridge, MA 02139, USA;3. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;4. Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USA;5. Department of Neurology & Neurosurgery, McGill University, Montreal, Canada H3A 2B4 |
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| Abstract: | Tissue engineering aims to improve the function of diseased or damaged organs by creating biological substitutes. To fabricate a functional tissue, the engineered construct should mimic the physiological environment including its structural, topographical, and mechanical properties. Moreover, the construct should facilitate nutrients and oxygen diffusion as well as removal of metabolic waste during tissue regeneration. In the last decade, fiber-based techniques such as weaving, knitting, braiding, as well as electrospinning, and direct writing have emerged as promising platforms for making 3D tissue constructs that can address the abovementioned challenges. Here, we critically review the techniques used to form cell-free and cell-laden fibers and to assemble them into scaffolds. We compare their mechanical properties, morphological features and biological activity. We discuss current challenges and future opportunities of fiber-based tissue engineering (FBTE) for use in research and clinical practice. |
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| Keywords: | Tissue engineering Fiber-based techniques Scaffold fabrication Cell-laden constructs |
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