Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue |
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| Authors: | Shimazawa Rumiko Gochomori Mika Shirai Ryuichi |
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| Affiliation: | Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
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| Abstract: | Compounds (6a-e) were synthesized by phosphorylation of hydrophobic perhydroindan derivatives derived from vitamin D(3), and were found to show strong inhibitory activity towards dual-specificity phosphatase Cdc25A (IC(50)=0.7-24.5 microM). |
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