A multipoint linkage map around the locus for myotonic dystrophy on chromosome 19 |
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| Authors: | H G Brunner H Smeets H M Lambermon M Coerwinkel-Driessen B A van Oost B Wieringa H H Ropers |
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| Affiliation: | Department of Human Genetics, University Hospital, 6500HB Nijmegen, The Netherlands. |
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| Abstract: | Employing 16 polymorphic DNA markers as well as the chromosome 19 centromere heteromorphism, we have performed a genetic linkage study in 26 families with myotonic dystrophy. Fourteen of these markers had been assigned previously to one of five different intervals of the 19cen-19q13.2 segment by using somatic cell hybrids. For the long arm of chromosome 19, a genetic map that encompasses 9 polymorphic markers and the DM gene has been constructed. Our studies indicate that the DM and CKMM genes map distal to the ApoC2-ApoE gene cluster and to the anonymous polymorphic markers D19S15 and D19S16, but proximal to the D19S22 marker. The orientation of DM and CKMM remains to be determined. |
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