Immunocytochemical analysis of the cytoskeleton of the human amniotic epithelium |
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Authors: | Hans Joachim Wolf Walter Schmidt Detlev Drenckhahn |
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Affiliation: | (1) Institut für Histologie und Embryologie, Universität Innsbruck, A-6010 Innsbruck, Austria;(2) Anatomisches Institut der Universität Würzburg, Koellikerstrasse 6, W-8700 Würzburg, Federal Republic of Germany |
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Abstract: | Summary The amniotic epithelium constitutes a diffusion barrier controlling the passage of solutes and water between the aminotic cavity and maternal circulation. With the present immunocytochemical approach, we have shown that several major components of the cytoskeleton, i.e., actin, -actinin, spectrin and ezrin, are preferentially associated with the apical and lateral cell surfaces of the human amniotic epithelium. Keratins are distributed throughout the entire cytoplasm, whereas vimentin mainly forms a perinuclear scaffold. These findings indicate a role of the various components of the cytoskeleton in the structural integrity and modulation of cell shape and junctional permeability. |
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Keywords: | Amniotic epithelium Cytoskeleton Filaments /content/x054nv44w177t747/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" >-Actinin Ezrin Immunocytochemistry Human |
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