Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13.3–ter |
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Authors: | M Bernard P Sanseau C Henry A Couturier C Prigent |
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Institution: | aDépartement de Biologie et Génétique du Développement, Groupe Cycle Cellulaire, CNRS UPR 41, Université de Rennes I, 35042, Rennes Cedex, France;bGenome Informatics, Glaxo-Wellcome, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom;cLaboratoire de Génétique et Biologie Cellulaire, Unité de Génétique, CHU Pontchaillou, 35033, Rennes Cedex, France |
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Abstract: | This report describes the identification of a cDNA encoding STK13, a third human protein kinase related to theDrosophilaAurora and the budding yeast Ipl1 kinases. After screening of a human placental cDNA library with aXenopus laeviscDNA encoding the pEg2 protein kinase and 5′ RACE on testis mRNA, a full-length cDNA was isolated. The chromosomal localization of STK13 on 19q13.3–ter between the markers D19S210 and D19S218 was established by a combination of somatic cell and radiation hybrid panel PCR screening. The localization of STK13 on human chromosome 19 was confirmed by fluorescencein situhybridization (FISH) using a genomic clone containing STK13 as a probe. |
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