A new non-HLA multigene family associated with thePERB11 family within theMHC class I region |
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Authors: | Laurent Pichon Annie Hampe Thierry Giffon Gwenaelle Carn Jean Yves Legall Veronique David |
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Institution: | (1) Department of Biochemistry and Molecular Biology, UPR 41 CNRS “Recombinaisons Génétiques” Faculté de Médecine, 2 avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France, FR |
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Abstract: | In an effort to initiate steps designed to characterize the idiopathic hemochromatosis disease gene, the HLA-A/HLA-F region where this gene is in disequilibrium linkage with some polymorphic markers has been overlapped by a yeast artificial
chromosome (YAC) contig. In order to achieve the physical mapping of these YACs and of the corresponding genomic region, we
subcloned one of the YACs involved. A computer-assisted analysis of the sequence of one subclone led to the isolation of a
potential exon that proved to belong to a new expressed messenger named HCGIX. After Southern blot analysis, the corresponding cDNA clone was found to belong to a new multigene family whose members are
dispersed throughout the HLA class I region and are closely associated with members of another recently described multigene family designated PERB11. The data reported here suggest that these two multigene families form a cluster that have been dispersed together throughout
the telomeric part of the major histocompatibility complex and have been involved in the genesis of this human class I region.
Received: 23 February 1996 / Revised: 23 April 1996 |
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