Mutant mouse models and their contribution to our knowledge of corpus luteum development,function and regression |
| |
Authors: | Luiz?E?Henkes John?S?Davis Email author" target="_blank">Bo?R?RuedaEmail author |
| |
Institution: | (1) Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 02114 Boston, Massachusetts, USA;(2) Olson Center for Women's Health, Department of Obstetrics and Gynecology, University of Nebraska Medical Center, 68198 Omaha, Nebraska, USA;(3) VA Medical Center, 68105 Omaha, Nebraska, USA |
| |
Abstract: | The corpus luteum is a unique organ, which is transitory in nature. The development, maintenance and regression of the corpus
luteum are regulated by endocrine, paracrine and autocrine signaling events. Defining the specific mediators of luteal development,
maintenance and regression has been difficult and often perplexing due to the complexity that stems from the variety of cell
types that make up the luteal tissue. Moreover, some regulators may serve dual functions as a luteotropic and luteolytic agent
depending on the temporal and spatial environment in which they are expressed. As a result, some confusion is present in the
interpretation of in vitro and in vivo studies. More recently investigators have utilized mutant mouse models to define the functional significance of specific
gene products. The goal of this mini-review is to identify and discuss mutant mouse models that have luteal anomalies, which
may provide some clues as to the significance of specific regulators of corpus luteum function. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|