Cytochrome c(6A) is a funnel for thiol oxidation in the thylakoid lumen |
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Authors: | Schlarb-Ridley Beatrix G Nimmo Robert H Purton Saul Howe Christopher J Bendall Derek S |
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Affiliation: | Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK. |
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Abstract: | Cytochrome c(6A) is a dithio-cytochrome recently discovered in land plants and green algae, and believed to be derived from the well-known cytochrome c(6). The function of cytochrome c(6A) is unclear. We propose that it catalyses the formation of disulphide bridges in thylakoid lumen proteins in a single-step disulphide exchange reaction, with subsequent transfer of the reducing equivalents to plastocyanin. The haem group of cytochrome c(6A) acts as an electron sink, allowing rapid resolution of a radical intermediate formed during reoxidation of cytochrome c(6A). Our model is consistent with previously published data on mutant plants, and the likely evolution of the protein. |
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Keywords: | Plastocyanin Disulphide exchange Cytochrome c6A Disulphide formation Thylakoid Photosystem |
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