Influence of potassium chloride on alcohol absorption |
| |
Authors: | H M Redetzki W L Dees J H Maddox |
| |
Affiliation: | 1. Department of Pharmacology and Therapeutics Louisiana State University School of Medicine in Shreveport, USA;2. Veterans Administration Hospital, Shreveport, Louisiana, USA |
| |
Abstract: | Simultaneous intragastric administration of large doses of KCl (430 mg/kg and 860 mg/kg) with ethanol (4 g/kg) significantly reduces blood alcohol levels and diminishes manifestations of alcohol intoxication in rats. It was shown with parenteral administration of alcohol that the effect is not related to an acceleration of alcohol metabolism. Analysis of alcohol concentrations of gastric and intestinal content as well as studies with animals whose stomachs were ligated at the pylorus revealed that KCl interferes with the absorption of alcohol through inhibition of gastric absorption and gastric emptying. The finding that equimolal concentrations of NaCl were unable to duplicate the described effects characterizes them as specific actions of the potassium ion. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |