Association Study of Gene LPP in Women with Polycystic Ovary Syndrome |
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| Authors: | Bo Zhang Han Zhao Tao Li Xuan Gao Qin Gao Rong Tang Jiangtao Zhang Zi-Jiang Chen |
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| Institution: | 1. Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, China.; 2. National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.; 3. The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, China.; 4. Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People’s Republic of China.; Baylor College of Medicine, United States of America, |
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| Abstract: | BackgroundPrevious genome-wide association study (GWAS) of polycystic ovary syndrome (PCOS) in Han Chinese population has found that SNPs in LPP gene were nominally significant in PCOS patients (P around 10E-05). Replication of the GWAS was applied to further confirm the relationship between LPP gene and PCOS.MethodsThree polymorphisms of LPP gene (rs715790, rs4449306, rs6782041) were selected and replicated in additional 1132 PCOS cases and 1142 controls. Genotyping of LPP gene was carried out by Taqman-MGB method.ResultsIn rs715790, the allele frequency is significantly different between the PCOS group and the control group. Meta-analysis showed that the allele frequencies of the three SNPs rs715790 (Pmeta = 1.89E-05, OR = 1.23), rs4449306 (Pmeta = 3.0E-04, OR = 1.10), rs6782041 (Pmeta = 2.0E-04, OR = 1.09), were significantly different between PCOS cases and controls.ConclusionsOur results suggest that LPP gene might be a novel candidate for PCOS. |
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