Peroxisome assembly: matrix and membrane protein biogenesis |
| |
Authors: | Ma Changle Agrawal Gaurav Subramani Suresh |
| |
Institution: | 1Institute for Genetics, Centre for Molecular Medicine, Cologne Excellence Cluster: Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50674 Cologne, Germany;2Department of Medicine, National Jewish Health, Denver, CO 80206;3Max Planck Institute for Biology of Aging, 50931 Cologne, Germany |
| |
Abstract: | Mitochondria are dynamic organelles whose functional integrity requires a coordinated supply of proteins and phospholipids. Defined functions of specific phospholipids, like the mitochondrial signature lipid cardiolipin, are emerging in diverse processes, ranging from protein biogenesis and energy production to membrane fusion and apoptosis. The accumulation of phospholipids within mitochondria depends on interorganellar lipid transport between the endoplasmic reticulum (ER) and mitochondria as well as intramitochondrial lipid trafficking. The discovery of proteins that regulate mitochondrial membrane lipid composition and of a multiprotein complex tethering ER to mitochondrial membranes has unveiled novel mechanisms of mitochondrial membrane biogenesis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|