硒对大鼠心、肝、肌、胰、肺和肾脏细胞线粒体~(45)Ca摄取的影响

用低硒饲料和该饲料补硒分别喂大鼠,对比观察硒对动物心、肝,肌、胰、肺和肾脏线粗体~(45)Ca摄取及心肌线粒体呼吸的影响。结果表明硒非常显著地刺激此六脏器细胞线粒体钙摄取,其中,对心、肝、肌的刺激强大而稳定;对胰、肺,在温育过程中逐渐增强;对肾则稍差。硒还非常显著地刺激心肌线粒体呼吸功能。提示硒对维持整体线粒体钙运转及心肌线粒体呼吸功能具重要作用。

The Effects of Selenium on ~(45)Ca Uptake in Mitochondria From Myocardia, Liver, Muscle, Pancreas, Lung and Kidney in Rat

In order to determine the effects of Se on Ca uptake by mitoehondria in whole-body, we inverstigated the counts of ~(45)Ca uptaken by mitochondria from myocardia, liver, muscle, pancreas, lung and kidney and myocardial mitochondrial respiratory functions in rats fed separatly with a Se-deficient (0.009mg Se/kg) diet and the diet supplemented(0. 232 mg Se/kg)as selenite The results show that dietary selenium has high significantly stimulative efffcts on Ca uptake by mitochondria from these six organs, among them, myocardia,liver and muscle are most strongly stimulated,and the stimulation effects on mitochondria in pancreas and lung gradually incraese in the course of incubation,while stimulation effects on mitochondria in kidney are weak. Besides can also remarkbly stimulate respiratory functions. The present restlts suggest that Se can maintain mitochondrial normal Ca transport in whole-body and myocardial mitochondrial respiratory function in rat.