Effects of des-tyr1 -γ-endorphin on dopamine release from various rat brain regions in vitro |
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Authors: | Hans Schoemaker Victor J Nickolson |
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Institution: | Dept. CNS Pharmacology, Scientific Development Group, Organon Kloosterstraat 1, Oss, The Netherlands |
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Abstract: | In rat striatum, nucleus accumbens and frontal cortex slices 6×10?8M of the potential neuroleptic peptide des-Tyr-γ-endorphin (DTγE) did not affect basal dopamine release but depressed K+-evoked release. Haloperidol at 5×10?6M increased both basal and K+-induced release in striatal and nucleus accumbens slices whereas it increased only basal dopamine release in frontal cortex slices. At 5×10?8M haloperidol, however, had no effect. It is concluded that DTγE may decrease dopaminergic activity in the brain by depressing depolarization-induced dopamine release, possibly via a presynaptic mechanism. |
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