Is prostacyclin the major pro-inflammatory prostanoid in joint fluid? |
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| Authors: | MJ Brodie CN Hensby A Parke D Gordon |
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| Institution: | 1. Department of Clinical Pharmacology and Rheumatology, Royal Postgraduate Medical School, Ducane Road, London W12 0HS, UK;1. Department of Pharmacology, Royal College of Surgeons, Lincoln''s Inn Field, London WC2, UK |
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| Abstract: | Prostanoid levels were measured in 10 samples of synovial fluid from 8 patients with rheumatoid disease. 6-Oxo prostaglandin F1α (6-oxo-PGF1α), the stable chemical hydrolysis product of prostacyclin, was present in higher concentration than prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α) and thromboxane B2 (TXB2). There were significant correlations between the concentrations of 6-oxo-PGF1α and TXB2 (p < 0.001) and PGE2 and PGF2α (p < 0.01). Full mass spectra of 6-oxo-PGFlα and TXB2 were obtained from the joint fluid of one untreated patient. Prostacyclin may be involved in the genesis and maintenance of the acute inflammatory reaction in arthritic joints. |
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