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Mechanism of alteration of the functional fraction of lipoprotein lipase in rat heart |
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| Authors: | Kathryn E. Kronquist Mary E. Pedersen Michael C. Schotz |
| Affiliation: | 1. Research Service, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073, USA;2. Department of Medicine, School of Medicine and Division of Environmental and Nutritional Sciences, School of Public Health, University of California at Los Angeles, Los Angeles, California 90024, U.S.A. |
| Abstract: | Feeding glucose to fasted rats resulted in a decrease in the activity of heparin-releasable lipoprotein lipase in heart perfusates. Upon feeding fat to glucose-fed animals the level of heparin-releasable lipoprotein lipase increased 10–14 fold. An immunological titration was used to determine whether the changes in lipase activity following the various nutritional treatments were due to changes in the amount of enzyme present or to activation/inactivation processes. These data suggest that changes in the enzyme activity are due to alteration in the quantity of lipoprotein lipase protein. |
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