Inhibition of peristaltic activity in the guinea-pig ileum by specific stress stimulus; its reversal by naloxone and indomethacin |
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Authors: | Ondřej Kadlec Jiří Horáček |
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Institution: | Institute of Pharmacology, Academy of Sciences, Prague 2, Albertov 4, 128 00, Czechoslovakia |
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Abstract: | During continuous peristaltic reflex activity of the isolated guinea-pig ileum a model stress stimulus, elevated intraluminal pressure (120 mm H2O) plus increased longitudinal tension (3 g) was applied for 2 min. The resulting inhibition of peristalsis outlasted the initial stimulus by several min. The inhibitory interval was shortened or abolished in the presence of naloxone (0.5 μM), an opiate receptor antagonist, or in the preparations made acutely tolerant to morphine. This seems to suggest an involvement of endorphins. An inhibition of endogenous prostaglandin synthesis by indomethacin (5 μM) decreased the amplitude of peristaltic longitudinal muscle contractions, and these contractions were increased in response to the stress stimulus in the presence of naloxone. Thus the response of the guinea-pig ileum to stress stimulation could be profoundly modified by an interference with endorphin and prostaglandin systems. |
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