Plasma normetanephrine: A biochemical marker of sympathetic nerve function in man |
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| Authors: | Kiyoshi Kobayashi Vincent DeQuattro Joseph Bornheimer Rainer Kolloch Lino Miano |
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| Institution: | 1. Hypertension Service Department of Medicine University of Southern California, USA;2. School of Medicine Department of Medicine White Memorial Medical Center Los Angeles, California 90033, USA |
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| Abstract: | The concentration of the catecholamines in plasma are regarded by many investigators as biochemical markers of sympathoadrenal activity in man. This study was designed to: 1) assess the relationship of normetanephrine (NMN), the metabolite of norepinephrine (NE) most likely to represent degration of newly synthesized and released “active” norepinephrine, to that of norepinephrine in plasma of normal volunteers and 2) to determine regional variations in plasma normetanephrine concentrations at venous and arterial sites of patients undergoing cardiac catherization. The findings suggest that 1) plasma normetanephrine reflects sympathoadrenal activity and neurotransmitter production at both peripheral neuronal and adrenal medullary sites and 2) there is net removal of normetanephrine by liver and kidney. Plasma normetanephrine should provide assistance in the biochemical assessment of sympathoadrenal tone in man and in patients with various autonomic disorders. |
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