Fibrinolytic and coagulation activity level during formation of experimental thrombus in dog's saphena vein |
| |
| Authors: | K. Sasaki M. Hatsuoka N. Toki H. Sumi T. Makita |
| |
| Affiliation: | 1. Veterinary Anatomy, Yamaguchi University, Yamaguchi City 753, Japan;1. Department of Dermatology, School of Medicine Hiroshima University 1–2, Kasumi-cho, Hiroshima City 734 Japan |
| |
| Abstract: | We could success in formation of the experimental thrombus by direct insertion of bovine fibrinogen into the lateral saphena vein of the dog. This method enabled us to clearly confirm the thrombus formation by X-ray micrograph. It was confirmed that this operation did not affect fibrinolytic and coagulation factors of experimental dogs. Reproducibility and stability of the result were also confirmed. So this experimental thrombus formation model is versatile for pharmacodynamic screening tests of the fibrinolytic enzyme system. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
