Effects of continuous gastric infusion of food dyes on developing rat pups |
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Authors: | James R Goldenring Robert S Wool Bennett A Shaywitz David K Batter Donald J Cohen J Gerald Young Martin H Teicher |
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Institution: | Laboratories of Developmental Neurobiology and Developmental Neurochemistry Yale University School of Medicine New Haven, Connecticut, USA |
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Abstract: | The consequences of chronic percutaneous gastric infusion of food dyes on the activity levels and shock avoidance performance of normal developing rats and those treated with 6-hydroxydo p-amine (6-OHDA) were investigated. All pups were artificially reared from four days of age and a liquid diet containing either food dyes (D) or no colorings (N) was infused into both 6-OHDA (T) and sham-treated pups (V). Pups receiving food dyes were significantly more active than comparable pups not receiving food dyes at all ages tested, an effect observed in both 6-OHDA and shamtreated pups. Pups treated with food dyes exhibited an impaired avoidance performance in a shuttle box at 28 days of age. VD and TN pups displayed an over 100% impairment in avoidance performance in comparison with VN pups. These results suggest that food dyes and/or their metabolites may exert deleterious effects on the behavioral repertoire of the developing rat pup. |
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