Bombesin acts in preoptic area to produce hypothermia in rats |
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| Authors: | Quentin J. Pittman Yvette Taché Marvin R. Brown |
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| Affiliation: | 1. The Salk Institute Post Office Box 85800 Arthur Vining Davis Center for Behavioral Neurobiology San Diego, California 92138, USA;2. The Salk Institute Post Office Box 85800 Peptide Biology Laboratory San Diego, California 92138, USA |
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| Abstract: | To determine a neuroanatomic location where bombesin produces hypothermia, bombesin or an inactive bombesin analog, [D-Trp8]-bombesin, were microinjected in nanogram quantities into various regions of the brain of unanesthetized, unrestrained, cold-exposed rats. Bombesin, but not [D-Trp8]-bombesin, produced hypothermia when injected into or near the preoptic area, whereas injections into other forebrain and midbrain areas failed to lower body temperature. These results support a possible involvement of a bombesin-like peptide in thermoregulation. |
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