Measurement of 6-hydroxymelatonin in human urine and its diurnal variations |
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| Authors: | M. Tetsuo S.P. Markey I.J. Kopin |
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| Affiliation: | Laboratory of Clinical Science National Institute of Mental Health Bethesda, Maryland 20205, USA |
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| Abstract: | A gas chromatographic-mass spectrometric assay has been developed and applied to the measurement of the major melatonin metabolite in human urine. In seven normal adult male subjects, the mean daily urinary conjugated 6-hydroxymelatonin was 15.5 μg (6.5 ? 22.8 μg rang). Urine samples at 6 hour intervals clearly demonstrated a ten-fold diurnal variation, from 0.8 μg/6 hr during the day to 8.6 μg/6 hr at night. |
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