Postnatal development of the cholecystokinin-gastrin family of peptides in the brain and gut of rat |
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Authors: | Michel Noyer Ngoc Diem Bui Monique Deschodt-Lanckman Patrick Robberecht Marie-Claire Woussen Jean Christophe |
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Institution: | Department of Biochemistry and Nutrition, School of Medicine, Université Libre de Bruxelles, Boulevard de Waterloo 115, B-1000 Brussels, Belgium |
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Abstract: | The average levels of CCK-8- and CCK-like peptides present in aqueous and acidic extracts of the brain of the newborn rat were, respectively, 5.3 and 2.9 pmol/g wet weight. These low levels increased 20- and 10-fold, respectively, so as to attain, at 25–30 days post partum, values comparable to those found in adult brain. There was also a rapid deposition of CCK-gastrin-like peptides in the whole gut between day 20 post coitum and day 10 post partum, when maximal concentrations were attained. Later, less CCK-gastrin peptides than other gut components were accumulated during the progressive weaning of the young rats, so that the average concentrations of CCK-gastrin-like peptides were, at day 30, similar to those observed in adult gut. |
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Keywords: | CCK-39 CCK-33 CCK-8 CCK-4 : C-terminal triacontanonatriacontatria- octa- and tetrapeptide of cholecystokinin-pancreozymin |
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