Lack of stimulation of phasic LH release by catechol estrogens in the rat |
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| Authors: | Jorge F. Rodriguez-Sierra Charles A. Blake |
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| Affiliation: | Department of Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA |
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| Abstract: | The 2-hydroxylated metabolites of estrone (E1) and estradiol (E2) were tested for their ability to induce an increase in the concentration of LH in the serum of the prepuberal male or female rat. Neither catechol estrogen was capable of inducing increases in the concentration of LH in the serum of rats of either sex, but E1 and E2 induced a surge in serum LH in the prepuberal female rats. It appears that, despite previous claims, the role that catechol estrogens might play in the control of phasic LH release is negligible. |
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