The stimulatory effect of beta-endorphin on the plasma prolactin levels was diminished in the rats treated with 6-hydroxydopamine |
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| Authors: | Taiichiro Okajima Toshiharu Motomatsu Ken-ichi Kato Hiroshi Ibayashi |
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| Institution: | Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan |
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| Abstract: | Intraventicular injection of beta-endorphin (beta LPH61?91) in urethane anesthetized male rats led to a dose dependent increase of plasma prolactin levels. Intravenous injection of apomorphine completely abolished the stimulatory effect of beta-endorphin. Animals treated with 6-hydroxydopamine (6-OHDA) and 6-OHDA plus desmethylimipramine showed inhibition of beta-endorphin induced prolactin release. These results suggest that beta-endorphin presynaptically inhibits the activity of dopaminergic neurones, leading to the stimulation of plasma prolactin levels. |
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