Metabolism of carbon tetrachloride to phosgene |
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Authors: | VL Kubic MW Anders |
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Institution: | Department of Pharmacology University of Minnesota Minneapolis, Minnesota 55455, USA |
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Abstract: | Aerobic incubation of hepatic microsomal fractions in the presence of carbon tetrachloride, NADPH and cysteine resulted in the formation of phosgene which was identified by gas chromatography/mass spectrometry as the adduct, 2-oxothiazolidine-4-carboxylic acid, formed by its reaction with cysteine. 13C]-Carbon tetrachloride was metabolized to 2-13C]-oxothiazolidine-4-carboxylic acid the , when carbon tetrachloride was incubated in the presence of 18O]-O2, 2- 18O]-oxothiazolidine-4-carboxylic acid was formed. The reaction was inhibited by carbon monoxide showing the involvement of the cytochrome P-450-dependent mixed function oxidase system. The metabolism of carbon tetrachloride to phosgene may play a role in the production of hepatotoxicity by this compound. |
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