[3H] spiroperidol binding to a putative dopaminergic receptor in rat pituitary gland |
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| Authors: | Ennio Stefanini Paola Devoto Anna M Marchisio Francesca Vernaleone Robert Collu |
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| Institution: | Institute of Pharmacology and Pharmacognosy University of Cagliari, Cagliari, Italy |
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| Abstract: | A class of high affinity DA receptor sites has been identified with 3H] SPIR in the anterior and pisterior lobes of rat pituitary gland. Competitive studies with DA receptor antagonists and agonists clearly demonstrated that 3H] SPIR stereospecifically labels a true dopaminergic receptor in both lobes. The physiological significance of these receptors, although still unclear, may be that of controlling the secretion of pituitary hormones and peptides. |
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