Effect of an abundant human skin melanosomal 66 kDa protein (MP 66) on m urine tyrosinase: Its physiological implications on melanogenesis |
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| Authors: | Badisa Ramesh Babu Ganeshrao Diwakar Abburi Ramaiah Tasneem Fatma |
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| Affiliation: | (1) Department of Biophysics, All India Institute of Medical Sciences, 110 029 New Delhi, India;(2) Department of Biochemistry, All India Institute of Medical Sciences, 110 029 New Delhi, India;(3) Centre for Biosciences, Lamia Millia Islamia, 110 025 New Delhi, India |
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| Abstract: | A single polypeptide protein (MP 66) of molecular weight 66 kDa purified to homogeneity from melanosomes of normal human skin epidermal melanocytes, was partially characterized. The isoelectric point of MP 66 is in the range of 7.3 to 7.6. This protein, which was shown to inhibit partially purified human skin tyrosinase activity at pH 6.8, also inhibits murine tyrosinase at pH 6.8. However, at pH 5.0, it stimulates murine tyrosinase activity. The physiological implications of these results are discussed. |
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| Keywords: | Melanosomal proteins tyrosinase related proteins tyrosinase activation and inhibition |
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