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The offspring of marriage between two first cousins with the same reciprocal translocation t(2;7)(p11;q31) |
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| Authors: | G Simoni L Dalprà G L Terzoli F Rossella M G Tibiletti |
| Institution: | (1) Clinica Ostetrica e Ginecologica, Unità di Medicina Preventiva Perinatale, Università di Milano, Via Commenda 12, I-Milano, Italy;(2) Laboratorio di Anatomia e Istologia Patologica, Sez. di Citogenetica, Istituti Clinici di Perfezionamento, I-Milano, Italy |
| Abstract: | Summary A marriage between two first cousins who have the same 2/7 balanced translocation is reported. The chromosome rearrangement was primarily detected in amniotic fluid cells cultured for prenatal chromosome analysis because of advanced maternal age. The translocation was also found in the couple's two normal children and in three other members of the family. The possible zygotic chromosome constitutions following 2:2 meiotic segregation in consanguineous parents with the same translocation are discussed. |
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