Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in <Emphasis Type="Italic">Pseudomonas</Emphasis> bacteria |
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| Authors: | Patrick Browne Matthieu Barret Fergal O'Gara John P Morrissey |
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| Institution: | 1.BIOMERIT Research Centre,Microbiology Department University College Cork,Cork,Ireland;2.Microbiology Department University College Cork,Cork,Ireland |
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| Abstract: | Background Catabolite repression control (CRC) is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of
CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation
of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. |
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