Age-dependent axonal expression of potassium channel proteins during development in mouse hippocampus |
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Authors: | Harald Prüss Gisela Grosse Irene Brunk Rüdiger W Veh Gudrun Ahnert-Hilger |
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Institution: | 1. Institute for Integrative Neuroanatomy, Charité University Medicine, Berlin, Philippstr. 12, 10115, Berlin, Germany
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Abstract: | The development of the hippocampal network requires neuronal activity, which is shaped by the differential expression and
sorting of a variety of potassium channels. Parallel to their maturation, hippocampal neurons undergo a distinct development
of their ion channel profile. The age-dependent dimension of ion channel occurrence is of utmost importance as it is interdependently
linked to network formation. However, data regarding the exact temporal expression of potassium channels during postnatal
hippocampal development are scarce. We therefore studied the expression of several voltage-gated potassium channel proteins
during hippocampal development in vivo and in primary cultures, focusing on channels that were sorted to the axonal compartment.
The Kv1.1, Kv1.2, Kv1.4, and Kv3.4 proteins showed a considerable temporal variation of axonal localization among neuronal
subpopulations. It is possible, therefore, that hippocampal neurons possess cell type-specific mechanisms for channel compartmentalization.
Thus, age-dependent axonal sorting of the potassium channel proteins offers a new approach to functionally distinguish classes
of hippocampal neurons and may extend our understanding of hippocampal circuitry and memory processing. |
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