Computational analysis and modeling of cleavage by the immunoproteasome and the constitutive proteasome |
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| Authors: | Carmen M Diez-Rivero Esther M Lafuente Pedro A Reche |
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| Institution: | (1) Laboratory of Immunomedicine, Department of Microbiology I-Immunology, Facultad de Medicina, Universidad Complutense de Madrid, Ave Complutense S/N, Madrid, 28040, Spain;(2) Department of Microbiology I-Immunology, Facultad de Medicina, Universidad Complutense de Madrid, Ave Complutense S/N, Madrid, 28040, Spain |
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| Abstract: | Background Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the
proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide ligands
(P1 residue of cleavage site). There are two types of proteasomes, the constitutive form, expressed in most cell types, and the
immunoproteasome, which is constitutively expressed in mature dendritic cells. Protective CD8 T cell epitopes are likely generated
by the immunoproteasome and the constitutive proteasome, and here we have modeled and analyzed the cleavage by these two proteases. |
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