Immunohistochemical demonstration of catecholaminergic cell bodies in the spinal cord of the rat |
| |
| Authors: | M Dietl M Arluison P Mouchet C Feuerstein M Manier J Thibault |
| |
| Institution: | (1) Laboratoire de Cytologie, CNRS, ERA 884, Université Pierre et Marie Curie, 7 Quai Saint Bernard, F-75005 Paris, France;(2) Laboratoire de Neurophysiologie, CNRS, RCP 643, CHU de Grenoble, Pavillon de Neurologie, BP 217 X, F-38043 Grenoble Cedex, France;(3) Laboratoire de Biochimie Cellulaire, Collège de France, F-75231 Paris Cedex 05, France;(4) Ludwig Boltzmann-Institut für klinische Neurobiologie, Krankenhaus Wien-Lainz, Wolkersbergenstraße 1, A-1130 Wien, Austria |
| |
| Abstract: | Summary In order to elucidate the anatomy of the spinal dopaminergic system, an immunohistochemical study using a tyrosine-hydroxylase (TH) antibody was undertaken in the rat. Intracisternal 6-hydroxydopamine (6-OHDA) injections were administered to destroy most of the noradrenergic fibres that descende to the spinal cord while preserving the dopaminergic fibres. The density of the remaining TH-like immunoreactive fibres was relatively low at all levels of the spinal cord; the highest density was observed in layers III, IV and X. In addition, we report the first evidence for the existence of TH-like immunoreactive cell bodies at definite levels (especially sacral) of the spinal cord. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
