A possibilistic framework for constraint-based metabolic flux analysis |
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Authors: | Francisco Llaneras Antonio Sala Jesús Picó |
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Affiliation: | (1) Instituto de Autom?tica AI2, Universidad Polit?cnica de Valencia, Camino de Vera s/n, 46022, Spain |
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Abstract: | Background Constraint-based models allow the calculation of the metabolic flux states that can be exhibited by cells, standing out as a powerful analytical tool, but they do not determine which of these are likely to be existing under given circumstances. Typical methods to perform these predictions are (a) flux balance analysis, which is based on the assumption that cell behaviour is optimal, and (b) metabolic flux analysis, which combines the model with experimental measurements. |
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