A mapped set of DNA markers for human chromosome 17 |
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| Authors: | Y Nakamura M Lathrop P O'Connell M Leppert D Barker E Wright M Skolnick S Kondoleon M Litt J M Lalouel |
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| Institution: | Howard Hughes Medical Institute, University of Utah Health Sciences Center, Salt Lake City 84132. |
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| Abstract: | We have developed and mapped by genetic linkage a primary set of markers for chromosome 17. The map consists of 21 loci derived from 27 probe/enzyme systems, including eight highly informative markers at loci containing a variable number of tandemly repeated DNA sequences (VNTRs). The map is continuous from the telomeric region of the short arm to the telomeric region of the long arm, covering estimated genetic distances of 218 cM in males and 279 cM in females. The average heterozygosity among all 21 loci in the population sample analyzed is 58%; 77% heterozygosity was observed among the eight VNTR markers that were highly informative. This map will make it possible to detect by linkage the location of genetic defects associated with chromosome 17 and will also provide anchor points for a high-resolution map of this chromosome. |
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