Interaction Between Gustatory Depolarizing Receptor Potential and Efferent-Induced Slow Depolarizing Synaptic Potential in Frog Taste Cell |
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Authors: | Toshihide Sato Kazuhisa Nishishita Yukio Okada Kazuo Toda |
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Institution: | (1) Division of Integrative Sensory Physiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan;(2) Division of Oral Pathopharmacology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan |
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Abstract: | Electrical stimulation of parasympathetic nerve (PSN) efferent fibers in the glossopharyngeal nerve induced a slow depolarizing
synaptic potential (DSP) in frog taste cells under hypoxia. The objective of this study is to examine the interaction between
a gustatory depolarizing receptor potential (GDRP) and a slow DSP. The amplitude of slow DSP added to a tastant-induced GDRP
of 10 mV was suppressed to 60% of control slow DSPs for NaCl and acetic acid stimulations, but to 20–30% for quinine–HCl (Q-HCl)
and sucrose stimulations. On the other hand, when a GDRP was induced during a prolonged slow DSP, the amplitude of GDRPs induced
by 1 M NaCl and 1 M sucrose was suppressed to 50% of controls, but that by 1 mM acetic acid and 10 mM Q-HCl unchanged. It
is concluded that the interaction between GDRPs and efferent-induced slow DSPs in frog taste cells under hypoxia derives from
the crosstalk between a gustatory receptor current across the receptive membrane and a slow depolarizing synaptic current
across the proximal subsynaptic membrane of taste cells. |
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Keywords: | Basic taste stimuli Gustatory efferent synapse Parasympathetic nerve Receptor potential Slow depolarizing synaptic potential Frog taste cell |
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