Effects of acute and chronic coingestion of AlCl3 with citrate or polyphenolic acids on tissue retention and distribution of aluminum in rats |
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Authors: | Zeyuan Deng Charles Coudray Laurent Gouzoux Andrzej Mazur Yves Rayssiguier Denise Pépin |
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Institution: | Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques et Micronutriments, INRA Center de Clermont-Ferrand/Theix, Saint Genès Champanelle, France. |
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Abstract: | Aluminum (Al) is toxic to certain biological systems and has been implicated as a neurotoxic agent in the pathogenesis of
Alzheimer’s disease. Intestinal absorption of Al is very low (0.1%), but many organic dietary components are potential chelators
of Al and may enhance its absorption and tissue distribution. We examined the effects of acute and chronic coingestion of
AlCl3 with different polyphenolic acids on Al retention and compared to citrate in rats. In experiment 1, animals fasted for 14
h were dosed orally with demineralized water, Al chloride, Al chloride plus sodium citrate, or Al chloride plus a polyphenol
acid. Blood samples were taken before and 2 h after the gavage and animals were killed 6 h later. In experiment 2, the rats
were adapted on a purified diet for 1 wk and received the following for 4 wk in their experimental diets: AlCl3, except group 1, plus citrate or a polyphenol acid, except groups 1 and 2. Animals were killed and blood and tissues were
sampled. In experiment 1, citrate highly enhanced Al absorption and its tissue retention. Gallic and chlorogenic acids significantly
increased tibia and kidney Al levels compared to the Al group. In experiment 2, Al levels in the urine were significantly
increased in all the Al groups compared to the control group. Significantly higher Al levels in the tibia, kidney, and brain
were observed in the citrate group and a significant increase in brain Al level was also noted in the chlorogenic acid group
compared to AlCl3 group. This may suggest a possible relation structure-activity of polyphenol acids. However, further studies are necessary
to better understand the influence of polyphenol acids on Al metabolism, in particular that of chlorogenic acid. |
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Keywords: | Aluminum absorption toxicity polyphenol citrate rat |
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